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The Enantioselective Preparation of a,b-unsaturated Cyanohydrins via Oxynitrilase. The greatest challenge facing the pharmaceutical industry today is the development of synthetic methodologies that facilitate enantioselective access to molecules of biological importance. The enantioselective preparation of a,b-unsaturated cyanohydrins creates potential building blocks for single-enantiomer medicinal compounds. Cyanohydrins are rich with chemical functionality that offer the organic chemist unique synthetic versatility. We have successfully prepared several chiral a,b-unsaturated cyanohydrins from their corresponding conjugated achiral aldehydes with good to excellent enantioselectivity. A chiral shift reagent Eu(hfc)3 was utilized to quantitatively determine enantiomeric excess via 1H NMR.
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