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Investigations on the Interactions of a Tranquilizer with
Phospholipidbilayers.
It has been found that small
molecules such as alcohols and certain phenothiazine drugs are capable of perturbing and
altering the phase transitions of phosphatidylcholine bilayers. The technique of
differential scanning calorimetry (DSC) was applied to study the thermotropic phase
behavior of dimyristoylphosphatidylcholine (DMPC) with the introduction of low mole
percentages of chlorpromazine hydrochloride (CPZ). The observation of additional peaks
with the pre-transition (L ' P') and the main transition (P ' L) suggests the presence of
mixed phases. The general lowering of pre-transition enthalpies and stabilization of main
transition enthalpies also provide insight into the dynamics of the lipid system. |
